Luteolin

Cayman Chemical Item Number 10004161

(CAS 491-70-3)

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Description

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets.1 Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.2 Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.3 Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.4

1. Morton, L.W., Caccetta, R.A., Puddey, I.B., et al. Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27 152-159 (2000).

2. Ueda, H., Yamazaki, C., and Yamazaki, M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol Pharm Bull 25(9) 1197-1202 (2002).

3. Sadik, C.D., Sies, H., and Schewe, T. Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action. Biochem Pharmacol 65 773-781 (2003).

4. Sartor, L., Pezzato, E., Dell'Aica, I., et al. Inhibition of matrix-proteases by polyphenols: Chemical insights for anti-inflammatory and anti-invasion drug design. Biochem Pharmacol 64 229-237 (2002).

Formal Name 2-​(3,​4-​dihydroxyphenyl)-​5,​7-​dihydroxy-​4H-​1-​benzopyran-​4-​one
CAS Number 491-70-3
Molecular Formula C15H10O6
Formula Weight 286.2
Formulation A crystalline solid
Purity ≥98%
λmax 255, 348 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1cc(O)​c2c(=O)​cc(oc2c1)​c1ccc(O)​c(O)​c1
InCHI Code
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​1S/C15H10O6/c16-8-4-11(19)​15-12(20)​6-13(21-14(15)​5-8)​7-1-2-9(17)​10(18)​3-7/h1-6,16-19H
InCHI Key
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IQPNAANSBPBGFQ-UHFFFAOYSA-N

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Luteolin is available in the following screening library:

Size Price Quantity Subtotal
10 mg $19.00 $0.00
50 mg $43.00 $0.00
100 mg $76.00 $0.00
500 mg $333.00 $0.00
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Pricing updated 2015-04-27. Prices are subject to change without notice.

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