4-hydroperoxy 2-Nonenal

Cayman Chemical Item Number 10004413

4-HpNE (CAS 7439-43-2)

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4-hydroxy Nonenal (4-HNE; Item No. 32100) is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress.1,2 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides.4 Analogous reactions are expected to occur with hydroperoxides from other ω-6 fatty acids, particularly arachidonic acid.

1. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).

2. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).

3. Sodum, R.S., and Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988).

4. Schneider, C., Tallman, K.A., Porter, N.A., et al. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J Biol Chem 276(24) 20831-20838 (2001).

  • 4-HpNE
Formal Name 4-​hydroperoxy-​2E-​nonenal
CAS Number 7439-43-2
Molecular Formula C9H16O3
Formula Weight 172.2
Formulation A solution in acetone
Purity ≥95%
λmax 217, 271 nm
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
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4-hydroperoxy 2-Nonenal is available in the following screening library:

Size Price Quantity Subtotal
500 µg $42.00 $0.00
1 mg $80.00 $0.00
5 mg $336.00 $0.00
10 mg $588.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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