CAY10434

Cayman Chemical Item Number 10005067

(CAS 769917-29-5)

CAY10434 (CAS 769917-29-5)

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Description

20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been previously shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 value of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

1 Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. J Vasc Res 34 237-243 (1997).

2 Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.. Am J Physiol 270 R217-R227 (1996).

3 Nakamura, T., Sato, M., Kakinuma, H., et al. Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. J Med Chem 46 5416-5427 (2003).

4 Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett 14 333-336 (2004).

Formal Name 6-​[4-​(1H-​imidazol-​1-​yl)phenoxy]-​N,​N-​dimethyl-​1-​hexanamine
CAS Number 769917-29-5
Molecular Formula C17H25N3O
Formula Weight 287.4
Formulation A solution in ethanol
Purity ≥98%
λmax 203, 242 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN(C)​CCCCCCOC1=CC=C(N2C=CN=C2)​C=C1
InCHI Code
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​1S/C17H25N3O/c1-19(2)​12-5-3-4-6-14-21-17-9-7-16(8-10-17)​20-13-11-18-15-20/h7-11,13,15H,3-6,12,14H2,1-2H3
InCHI Key
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FIFQJYUSSPRJIZ-UHFFFAOYSA-N

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CAY10434 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $86.00 $0.00
10 mg $152.00 $0.00
50 mg $665.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-16. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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