Source:recombinant N-terminal hexahistidine-tagged protein expressed in E. coli
Protein concentration:0.5 mg/ml
Fatty acid binding protein 1 (FABP1) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.1 FABP1 is composed of ten antiparallel β strands that form a barrel with a bigger binding pocket than the other FABPs allowing it to accommodate two fatty acids. Expression of FABP1 is decreased in hepatoblastoma and hepatocellular carcinoma making the protein a potential tumor marker. Moreover, studies have suggested FABP1 as a potential biomarker for both liver and kidney injury.1 Cayman’s FABP1 has been functionally characterized by a fluorescence displacement assay using the fluorescent fatty acid analogue 11-(dansyl amino)undecanoic acid (DAUDA). Both arachidonic acid and oleic acid effectively displace DAUDA from the FABP binding pocket in a concentration-dependent manner.
1Zimmerman, A.W., and Veerkamp, J.H.New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci591096-1116(2002).
Fatty Acid Binding Protein 1
Liver-Fatty Acid Binding Protein
A solution in 50 mM sodium phosphate, pH 7.2, containing 20% glycerol and 150 mM sodium chloride
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