Item № 10005263
CAS № 54857-86-2
Purity ≥98%
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5 mg $29.00 $0.00
10 mg $55.00 $0.00
50 mg $232.00 $0.00
100 mg $406.00 $0.00

Pricing updated 2015-10-13. Prices are subject to change without notice.

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  • 5-(Tetradecyloxy)-2-furoic Acid
  • RMI 14514

Inhibition of fatty acid synthase (FAS) by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines.1 TOFA is an inhibitor of fatty acid synthesis blocking the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC).2 Both cerulenin (at about 10 µg/ml) and TOFA (at about 1 µg/ml) are effective at blocking the incorporation of radiolabeled acetate into palmitate. However, TOFA reduces malonyl-CoA levels rather than elevating them, and TOFA is relatively non-toxic to various cancer cell lines. TOFA also attenuates the inhibition of feeding observed when FAS inhibitors such as cerulenin and C75 are administered to obese ob/ob mice.

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Technical Information
Formal Name 5-(tetradecyloxy)-2-furancarboxylic acid
CAS Number 54857-86-2
  • 5-(Tetradecyloxy)-2-furoic Acid
  • RMI 14514
Molecular Formula C19H32O4
Formula Weight 324.5
Purity ≥98%
Formulation A crystalline solid
λmax 278 nm
InChI Code 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Safety Data Sheet (SDS) 23 Kb PDF

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References & Background Reading
Product Description References

1. Moche, M., Schneider, G., Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. J Biol Chem 274(10) 6031-6034 (1999).

2. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 2379-2381 (2000).

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