DL-α-Lipoic Acid

Cayman Chemical Item Number 10005728

Thioctic acid (CAS 1077-28-7)

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DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.1,2,3 DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

1. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

2. Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4) 263-283 (1998).

3. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy*. Drug Metab Rev 29(4) 1025-1054 (1997).

  • Thioctic acid
Formal Name 1,​2-​dithiolane-​3-​pentanoic acid
CAS Number 1077-28-7
Molecular Formula C8H14O2S2
Formula Weight 206.3
Formulation A crystalline solid
Purity >95%
λmax 203, 333 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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DL-α-Lipoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 g $7.00 $0.00
5 g $32.00 $0.00
10 g $56.00 $0.00
25 g $123.00 $0.00
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Pricing updated 2015-08-01. Prices are subject to change without notice.

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