DL-α-Lipoic Acid

Cayman Chemical Item Number 10005728

Thioctic acid (CAS 1077-28-7)

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Description

DL-α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.1,2,3 DL-α-lipoic acid can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.

1. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

2. Randle, P.J. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14(4) 263-283 (1998).

3. Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The role of lipoic acid in the treatment of diabetic polyneuropathy*. Drug Metab Rev 29(4) 1025-1054 (1997).

Synonyms
  • Thioctic acid
Formal Name 1,​2-​dithiolane-​3-​pentanoic acid
CAS Number 1077-28-7
Molecular Formula C8H14O2S2
Formula Weight 206.3
Formulation A crystalline solid
Purity >95%
λmax 203, 333 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​CCCCC1SSCC1
InCHI Code
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​1S/C8H14O2S2/c9-8(10)​4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)​
InCHI Key
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AGBQKNBQESQNJD-UHFFFAOYSA-N

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DL-α-Lipoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 g $7.00 $0.00
5 g $32.00 $0.00
10 g $56.00 $0.00
25 g $123.00 $0.00
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Pricing updated 2015-07-01. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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