Quinestrol

Cayman Chemical Item Number 10006320

Estrovis®; Ethynyl Estradiol-3-cyclopentyl ether; W 3566 (CAS 152-43-2)

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Description

Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.1,2 It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.

1. Baumgardner, S.B., Condrea, H., Daane, T.A., et al. Replacement estrogen therapy for menopausal vasomotor flushes. Comparison of Quinestrol and conjugated estrogens.. Obstet Gynecol 51(4) 445-452 (1978).

2. Skouby, S.O. Criteria for the selection of an optimal estrogen replacement.. Gynecol Endocrinol 15 60-67 (2001).

Synonyms
  • Estrovis®
  • Ethynyl Estradiol-3-cyclopentyl ether
  • W 3566
Formal Name 3-​(cyclopentyloxy)-​19-​norpregna-​1,​3,​5(10)-​trien-​20-​yn-​17α-​ol
CAS Number 152-43-2
Molecular Formula C25H32O2
Formula Weight 364.5
Formulation A crystalline solid
Purity ≥98%
λmax 202, 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C[C@@]​12[C@@]​([H]​)​(CC[C@@]​2(O)​C#C)​[C@]​([C@]​3([H]​)​CC1)​([H]​)​CCC4=C3C=CC(OC5CCCC5)​=C4
InCHI Code
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​1S/C25H32O2/c1-3-25(26)​15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)​9-11-20(17)​21(22)​12-14-24(23,25)​2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1
InCHI Key
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PWZUUYSISTUNDW-VAFBSOEGSA-N

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Size Price Quantity Subtotal
100 mg $28.00 $0.00
250 mg $67.00 $0.00
500 mg $126.00 $0.00
1 g $224.00 $0.00
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Related Products

Diethylstilbestrol
Ethynyl Estradiol
Gestrinone

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