Item № 10006321
CAS № 5630-53-5
Purity >98%
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100 mg $15.00 $0.00
500 mg $60.00 $0.00
1 g $90.00 $0.00
5 g $300.00 $0.00

Pricing updated 2015-11-24. Prices are subject to change without notice.

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  • Livial
  • Liviella

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.1 Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.1 A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.2

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Technical Information
Formal Name 17α-hydroxy-7α-methyl-19-norpregn-5(10)-en-20-yn-3-one
CAS Number 5630-53-5
  • Livial
  • Liviella
Molecular Formula C21H28O2
Formula Weight 312.5
Purity >98%
Formulation A crystalline solid
SMILES O[C@@]1(C#C)CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])[C@H](C)CC4=C3CCC(C4)=O
InChI Code 1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 121 Kb PDF

Download Safety Data Sheet (SDS) 31 Kb PDF

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References & Background Reading
Product Description References

1. Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

2. Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

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