Tibolone

Cayman Chemical Item Number 10006321

Livial; Liviella (CAS 5630-53-5)

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Description

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.1 Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.1 A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.2

1. Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

2. Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

Synonyms
  • Livial
  • Liviella
Formal Name 17α-​hydroxy-​7α-​methyl-​19-​norpregn-​5(10)-​en-​20-​yn-​3-​one
CAS Number 5630-53-5
Molecular Formula C21H28O2
Formula Weight 312.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@]​1(C#C)​CC[C@@]​2([H]​)​[C@]​([C@]​3([H]​)​CC[C@@]​21C)​([H]​)​[C@H]​(C)​CC4=C3CCC(C4)​=O
InCHI Code
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​1S/C21H28O2/c1-4-21(23)​10-8-18-19-13(2)​11-14-12-15(22)​5-6-16(14)​17(19)​7-9-20(18,21)​3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1
InCHI Key
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WZDGZWOAQTVYBX-XOINTXKNSA-N

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Tibolone is available in the following screening library:

Size Price Quantity Subtotal
100 mg $15.00 $0.00
500 mg $60.00 $0.00
1 g $90.00 $0.00
5 g $300.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2015-03-29. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

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