Estriol

Cayman Chemical Item Number 10006484

16α-hydroxy-17β-estradiol; 1,3,5(10)-Estratriene-3,16α,17β-triol; E3 (CAS 50-27-1)

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Description

Estriol is a metabolite of estradiol and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.1 The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS) and serves as a direct marker of fetal adrenal gland activity.2 Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.4

1. Peter, M., Dörr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Horm Res 42 278-281 (1994).

2. Goodwin, T.M. A role for estriol in human labor, term and preterm. Am J Obstet Gynecol 180 S208-S213 (1999).

3. Voss, H.F. Hormonal pathways of preterm birth. Am J Obstet Gynecol 180 S226-S231 (1999).

4. . Steroid levels in humans. (1999 Apr 19).

Synonyms
  • 16α-hydroxy-17β-estradiol
  • 1,3,5(10)-Estratriene-3,16α,17β-triol
  • E3
Formal Name estra-​1,​3,​5(10)-​triene-​3,​16α,​17β-​triol
CAS Number 50-27-1
Molecular Formula C18H24O3
Formula Weight 288.4
Formulation A crystalline solid
Purity ≥95%
λmax 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc2c(CC[C@@H]​3C2CC[C@]​2(C)​[C@@H]​(O)​C(O)​CC32)​c1
InCHI Code
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​1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)​8-10(12)​2-4-14(13)​15(18)​9-16(20)​17(18)​21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
InCHI Key
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PROQIPRRNZUXQM-ZXXIGWHRSA-N

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Size Price Quantity Subtotal
100 mg $9.00 $0.00
500 mg $41.00 $0.00
1 g $72.00 $0.00
5 g $315.00 $0.00
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