Cayman Chemical Item Number 10006484

16α-hydroxy-17β-estradiol; 1,3,5(10)-Estratriene-3,16α,17β-triol; E3 (CAS 50-27-1)

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Estriol is a metabolite of estradiol and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.1 The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate (DHEAS) and serves as a direct marker of fetal adrenal gland activity.2 Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.4

1. Peter, M., Dörr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Horm Res 42 278-281 (1994).

2. Goodwin, T.M. A role for estriol in human labor, term and preterm. Am J Obstet Gynecol 180 S208-S213 (1999).

3. Voss, H.F. Hormonal pathways of preterm birth. Am J Obstet Gynecol 180 S226-S231 (1999).

4. . Steroid levels in humans. (1999 Apr 19).

  • 16α-hydroxy-17β-estradiol
  • 1,3,5(10)-Estratriene-3,16α,17β-triol
  • E3
Formal Name estra-​1,​3,​5(10)-​triene-​3,​16α,​17β-​triol
CAS Number 50-27-1
Molecular Formula C18H24O3
Formula Weight 288.4
Formulation A crystalline solid
Purity ≥95%
λmax 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
100 mg $9.00 $0.00
500 mg $41.00 $0.00
1 g $72.00 $0.00
5 g $315.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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