Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.1,2 Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. It is often used in combination with a progestin to induce estrus in domestic livestock.3 Estradiol benzoate binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM.4 This reflects a 6-10 fold reduction in binding affinity compared to estradiol.4
1Miller, W.L., and Tyrrell, J.B.The adrenal cortex. 3rd edition555-711(1995).
2Vance, D.E.Cholesterol and related derivatives. 2nd ed.725-748(1988).
3Cavalieri, J., Hepworth, G., and Macmillan, K.L.Ovarian follicular development in Holstein cows following synchronisation of oestrus with oestradiol benxoate and an intravaginal progesterone releasing insert for 5-9 days and duration of the oestrous cycle and concentrations of progesterone following ovulation. Anim Reprod Sci81177-193(2004).
4Matthews, J., Celius, T., Halgren, R., et al. Differential estrogen receptor binding of estrogenic substances: A species comparison. J Steroid Biochem Mol Biol74223-234(2000).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available