CAY10464

Cayman Chemical Item Number 10006545

(CAS 688348-37-0)

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Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar.1 CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations.2 It is inactive as an estrogen receptor ligands even at 100 µM.

1. Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2. de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name 1,​3-​dichloro-​5-​[(1E)-​2-​(4-​methoxyphenyl)ethenyl]-​benzene
CAS Number 688348-37-0
Molecular Formula C15H12Cl2O
Formula Weight 279.2
Formulation A crystalline solid
Purity ≥98%
λmax 212, 326 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1)​\C=C/c1cc(Cl)​cc(Cl)​c1
InCHI Code
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​1S/C15H12Cl2O/c1-18-15-6-4-11(5-7-15)​2-3-12-8-13(16)​10-14(17)​9-12/h2-10H,1H3/b3-2+
InCHI Key
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YDVZIQMQLZBUKX-NSCUHMNNSA-N

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CAY10464 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $17.00 $0.00
25 mg $40.00 $0.00
50 mg $77.00 $0.00
100 mg $136.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA

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