CAY10464 Exclusive

Cayman Chemical Item Number 10006545

(CAS 688348-37-0)

CAY10464 (CAS 688348-37-0)

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Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar.1 CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations.2 It is inactive as an estrogen receptor ligand even at 100 µM.

1 Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2 de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name 1,​3-​dichloro-​5-​[(1E)-​2-​(4-​methoxyphenyl)ethenyl]-​benzene
CAS Number 688348-37-0
Molecular Formula C15H12Cl2O
Formula Weight 279.2
Formulation A crystalline solid
Purity ≥98%
λmax 212, 326 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1)​\C=C/c1cc(Cl)​cc(Cl)​c1
InCHI Code
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​1S/C15H12Cl2O/c1-18-15-6-4-11(5-7-15)​2-3-12-8-13(16)​10-14(17)​9-12/h2-10H,1H3/b3-2+
InCHI Key
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YDVZIQMQLZBUKX-NSCUHMNNSA-N

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CAY10464 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $17.00 $0.00
25 mg $40.00 $0.00
50 mg $77.00 $0.00
100 mg $136.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-17. Prices are subject to change without notice.

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