Losartan (potassium salt)

Cayman Chemical Item Number 10006594

DuP-753; MK 954 (CAS 124750-99-8)

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Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is an AT1 receptor antagonist with a Ki value of 5-20 nM.3 It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.4,5 In humans, losartan controls hypertension while protecting renal function.6

1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37(2) 505-511 (2001).

2. Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression. Am J Hypertens 15 115S-122S (2002).

3. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J Biol Chem 269(24) 16533-16536 (1994).

4. Ge, J., Huang, D., Liang, C., et al. Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartan. Atherosclerosis 177 263-268 (2004).

5. Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al. Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br J Pharmacol 143 215-225 (2004 Jun 10).

6. Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions. J Cardiovasc Pharmacol 44 520-524 (2004).

  • DuP-753
  • MK 954
Formal Name 2-​butyl-​4-​chloro-​1-​[[2'-​(1H-​tetrazol-​5-​yl)[1,​1'-​biphenyl]-​4-​yl]methyl]-​1H-​imidazole-​5-​methanol,​ monopotassium salt
CAS Number 124750-99-8
Molecular Formula C22H23ClN6O • K
Formula Weight 461.0
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
10 mg $12.00 $0.00
50 mg $54.00 $0.00
100 mg $96.00 $0.00
500 mg $420.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-30. Prices are subject to change without notice.

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