Losartan (potassium salt)
Cayman Chemical Item Number 10006594
Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is an AT1 receptor antagonist with a Ki value of 5-
1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37(2) 505-511 (2001).
2. Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression. Am J Hypertens 15 115S-122S (2002).
3. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J Biol Chem 269(24) 16533-16536 (1994).
Ge, J., Huang, D., Liang, C., et al. Upregulation of lectinlike oxidized low-
Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al. Ouabain-
Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-
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Pricing updated 2015-04-18. Prices are subject to change without notice.
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