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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

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Losartan (potassium salt)

Cayman Chemical Item Number 10006594

DuP-753; MK 954 (CAS 124750-99-8)

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Description

Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is an AT1 receptor antagonist with a Ki value of 5-20 nM.3 It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.4,5 In humans, losartan controls hypertension while protecting renal function.6

1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. Hypertension 37(2) 505-511 (2001).

2. Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression. Am J Hypertens 15 115S-122S (2002).

3. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J Biol Chem 269(24) 16533-16536 (1994).

4. Ge, J., Huang, D., Liang, C., et al. Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartan. Atherosclerosis 177 263-268 (2004).

5. Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al. Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br J Pharmacol 143 215-225 (2004 Jun 10).

6. Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions. J Cardiovasc Pharmacol 44 520-524 (2004).

Synonyms
  • DuP-753
  • MK 954
Formal Name 2-​butyl-​4-​chloro-​1-​[[2'-​(1H-​tetrazol-​5-​yl)[1,​1'-​biphenyl]-​4-​yl]methyl]-​1H-​imidazole-​5-​methanol,​ monopotassium salt
CAS Number 124750-99-8
Molecular Formula C22H23ClN6O • K
Formula Weight 461.0
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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[H]​N1N=NN=C1C2=CC=CC=C2C3=CC=C(CN4C(CO)​=C(Cl)​N=C4CCCC)​C=C3.[K+]​
InCHI Code
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​1S/C22H23ClN6O.K/c1-2-3-8-20-24-21(23)​19(14-30)​29(20)​13-15-9-11-16(12-10-15)​17-6-4-5-7-18(17)​22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)​;/q;+1
InCHI Key
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VSEMWXMEXIKGTA-UHFFFAOYSA-N

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Size Price Quantity Subtotal
10 mg $12.00 $0.00
50 mg $54.00 $0.00
100 mg $96.00 $0.00
500 mg $420.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2015-03-01. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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