Thromboxane B1

Cayman Chemical Item Number 10006610

(CAS 64626-32-0)

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Dihomo-g-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2).1 The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase.2 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.2 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.

1. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

2. Manku, M.S., Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol.. Prostaglandins Med 3(2) 119-128 (1979).

Formal Name 9,​11,​15-​trihydroxy-​thrombox-​13-​en-​1-​oic acid
CAS Number 64626-32-0
Molecular Formula C20H36O6
Formula Weight 372.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Thromboxane B1 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $110.00 $0.00
5 mg $495.00 $0.00
10 mg $880.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

11-dehydro Thromboxane B2
2,3-dinor Thromboxane B1
2,3-dinor Thromboxane B2
Thromboxane B2
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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