Thromboxane B1

Cayman Chemical Item Number 10006610

(CAS 64626-32-0)

Thromboxane B1 (CAS 64626-32-0)

See more

Description

Dihomo-γ-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2).1 The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase.2 However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1.2 Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.

1 Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

2 Manku, M.S., Oka, M., and Horrobin, D.F. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol.. Prostaglandins Med 3(2) 119-128 (1979).

Formal Name 9,​11,​15-​trihydroxy-​thrombox-​13-​en-​1-​oic acid
CAS Number 64626-32-0
Molecular Formula C20H36O6
Formula Weight 372.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O[C@@H]​1[C@H]​(CCCCCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​OC(O)​C1
InCHI Code
Copy InCHI code to clipboard
​1S/C20H36O6/c1-2-3-6-9-15(21)​12-13-18-16(17(22)​14-20(25)​26-18)​10-7-4-5-8-11-19(23)​24/h12-13,15-18,20-22,25H,2-11,14H2,1H3,(H,23,24)​/b13-12+/t15-,16-,17-,18+,20?/m0/s1
InCHI Key
Copy InCHI key to clipboard
JSDWWNLTJCCSAV-VZBVYBAISA-N

Download free InCHI Key generation software

Thromboxane B1 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $110.00 $0.00
5 mg $495.00 $0.00
10 mg $880.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-20. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

11-dehydro Thromboxane B2
2,3-dinor Thromboxane B1
2,3-dinor Thromboxane B2
Thromboxane B2
Show all 4 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · Experimental Biology 2014 · San Diego, California · April 26-30, 2014 · Booth 323
Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?