(R)-Bromoenol lactone Exclusive

Cayman Chemical Item Number 10006800

(R)-BEL (CAS 478288-90-3)

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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.2 (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol 39 175-189 (1999).

2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. J Biol Chem 277(36) 32807-32814 (2002).

  • (R)-BEL
Formal Name 6E-​(bromoethylene)tetrahydro-​3R-​(1-​naphthalenyl)-​2H-​pyran-​2-​one
CAS Number 478288-90-3
Molecular Formula C16H13BrO2
Formula Weight 317.2
Formulation A solution in methyl acetate
Purity ≥98%
λmax 222, 280 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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(R)-Bromoenol lactone is available in the following screening library:

Size Price Quantity Subtotal
500 µg $25.00 $0.00
1 mg $45.00 $0.00
5 mg $188.00 $0.00
10 mg $300.00 $0.00
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Cart Total $0.00

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Pricing updated 2015-03-28. Prices are subject to change without notice.

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