(S)-Bromoenol lactone
Item № 10006801
CAS № 478288-94-7
Purity ≥98%
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500 µg $25.00 $0.00
1 mg $45.00 $0.00
5 mg $188.00 $0.00
10 mg $300.00 $0.00

Pricing updated 2015-11-30. Prices are subject to change without notice.

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  • (S)-BEL

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1 The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.2 (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.

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View Screening Libraries with (S)-Bromoenol lactone
Technical Information
Formal Name 6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl)-2H-pyran-2-one
CAS Number 478288-94-7
  • (S)-BEL
Molecular Formula C16H13BrO2
Formula Weight 317.2
Purity ≥98%
Formulation A solution in methyl acetate
λmax 223, 280 nm
SMILES Br/C=C1\CC[C@H](C(=O)O\1)c1cccc2ccccc12

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 86 Kb PDF

Download Safety Data Sheet (SDS) 36 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Balsinde, J., Balboa, M.A., Insel, P.A., et al. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol 39 175-189 (1999).

2. Jenkins, C.M., Han, X., Mancuso, D.J., et al. Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. J Biol Chem 277(36) 32807-32814 (2002).

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