ABH
Item № 10006862
CAS № 222638-65-5
Purity ≥95%
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1 mg $29.00 $0.00
5 mg $131.00 $0.00
10 mg $232.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

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Description
Synonyms
  • Amino-2-Borono-6-Hexanoic Acid

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. ABH is a slow-binding competitive inhibitor of human arginase II with Ki values of 0.25 µM and 8.5 nM at pH 7.5 and 9.5, respectively.1 ABH enhances both male and female sexual arousal responses in rabbits, an effect which may be due to increased NO bioavailability resulting from arginase inhibition.2 Inhibition of arginase is therefore a potential therapeutic target for the treatment of sexual arousal disorders.

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Technical Information
Formal Name 6-​borono-​L-​norleucine
CAS Number 222638-65-5
Synonyms
  • Amino-2-Borono-6-Hexanoic Acid
Molecular Formula C6H14BNO4
Formula Weight 175.0
Purity ≥95%
Formulation A crystalline solid
SMILES OB(O)​CCCC[C@H]​(C(O)​=O)​N
InChI Code ​1S/C6H14BNO4/c8-5(6(9)​10)​3-1-2-4-7(11)​12/h5,11-12H,1-4,8H2,(H,9,10)​
InChI Key HFKKMXCOJQIYAH-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 112 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356-9362 (2001).

2. Cama, E., Colleluori, D.M., Emig, F.A., et al. Human arginase II: Crystal structure and physiological role in male and female sexual arousal. Biochemistry 42 8445-8451 (2003).

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