Cayman Chemical Item Number 10006862

Amino-2-Borono-6-Hexanoic Acid (CAS 222638-65-5)

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L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. ABH is a slow-binding competitive inhibitor of human arginase II with Ki values of 0.25 µM and 8.5 nM at pH 7.5 and 9.5, respectively.1 ABH enhances both male and female sexual arousal responses in rabbits, an effect which may be due to increased NO bioavailability resulting from arginase inhibition.2 Inhibition of arginase is therefore a potential therapeutic target for the treatment of sexual arousal disorders.

1. Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356-9362 (2001).

2. Cama, E., Colleluori, D.M., Emig, F.A., et al. Human arginase II: Crystal structure and physiological role in male and female sexual arousal. Biochemistry 42 8445-8451 (2003).

  • Amino-2-Borono-6-Hexanoic Acid
Formal Name 6-​borono-​L-​norleucine
CAS Number 222638-65-5
Molecular Formula C6H14BNO4
Formula Weight 175.0
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $29.00 $0.00
5 mg $131.00 $0.00
10 mg $232.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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