ABH

Cayman Chemical Item Number 10006862

Amino-2-Borono-6-Hexanoic Acid (CAS 222638-65-5)

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Description

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. ABH is a slow-binding competitive inhibitor of human arginase II with Ki values of 0.25 µM and 8.5 nM at pH 7.5 and 9.5, respectively.1 ABH enhances both male and female sexual arousal responses in rabbits, an effect which may be due to increased NO bioavailability resulting from arginase inhibition.2 Inhibition of arginase is therefore a potential therapeutic target for the treatment of sexual arousal disorders.

1. Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356-9362 (2001).

2. Cama, E., Colleluori, D.M., Emig, F.A., et al. Human arginase II: Crystal structure and physiological role in male and female sexual arousal. Biochemistry 42 8445-8451 (2003).

Synonyms
  • Amino-2-Borono-6-Hexanoic Acid
Formal Name 6-​borono-​L-​norleucine
CAS Number 222638-65-5
Molecular Formula C6H14BNO4
Formula Weight 175.0
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OB(O)​CCCC[C@H]​(C(O)​=O)​N
InCHI Code
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​1S/C6H14BNO4/c8-5(6(9)​10)​3-1-2-4-7(11)​12/h5,11-12H,1-4,8H2,(H,9,10)​
InCHI Key
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HFKKMXCOJQIYAH-UHFFFAOYSA-N

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Size Price Quantity Subtotal
1 mg $29.00 $0.00
5 mg $131.00 $0.00
10 mg $232.00 $0.00
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