CMPF Exclusive

Cayman Chemical Item Number 10007133

(CAS 86879-39-2)

CMPF (CAS 86879-39-2)

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Description

Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.1 CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).2,3 CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.3 Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.3

1 Ishii, K., Okajima, H., Okada, Y., et al. Studies on furan fatty acids of salmon roe phospholipids. J Biochem 103(5) 836-839 (1988).

2 Lim, C., Bernard, B.F., De Jong, M., et al. A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia. J Clin Endocrinol Metab 76(2) 318-324 (1993).

3 Lim, C., Stockigt, J.R., Curtis, A.J., et al. A naturally occuring furan fatty acid enhances drug inhibition of thyroxine binding in serum. Metabolism 42(11) 1468-1474 (1993).

Formal Name 3-​carboxy-​4-​methyl-​5-​propyl-​2-​furanpropanoic acid
CAS Number 86879-39-2
Molecular Formula C12H16O5
Formula Weight 240.3
Formulation A crystalline solid
Purity ≥98%
λmax 260 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCc1oc(CCC(=O)​O)​c(C(=O)​O)​c1C
InCHI Code
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​1S/C12H16O5/c1-3-4-8-7(2)​11(12(15)​16)​9(17-8)​5-6-10(13)​14/h3-6H2,1-2H3,(H,13,14)​(H,15,16)​
InCHI Key
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WMCQWXZMVIETAO-UHFFFAOYSA-N

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Size Price Quantity Subtotal
500 µg $34.00 $0.00
1 mg $65.00 $0.00
5 mg $272.00 $0.00
10 mg $476.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-16. Prices are subject to change without notice.

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