The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.1 In male wistar rats, cetaben increased the activity of all peroxisomal enzymes examined in liver and kidney, whereas clofibrate showed a varied regulatory pattern.2 In addition to its effects on peroxisomes, cetaben inhibits cholesterol synthesis in the human hepatoma HepG2 cells resulting in reversible changes in Golgi morphology.3,4 It also blocked triglyceride synthesis by 99% and reduced cholesterol ester synthesis by >70% at a concentration of 50 µM in these same cells.4
1Chandoga, J., Hampl, L., Turecký, L., et al. Cetaben is an exceptional type of peroxisome proliferator. Int J Biochem26(5)679-696(1994).
2Chandoga, J., Rojeková, I., Hampl, L., et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol47(3)515-519(1994).
3Kovacs, W., Walter, I., and Stangl, H.Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochem Cell Biol115509-519(2001).
4Kovacs, W., Schrader, M., Walter, I., et al. The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochem Cell Biol12295-109(2004).
Hexadecylamino-p-amino Benzoic Acid
A crystalline solid
224, 304 nm
in continental US; may vary elsewhere
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available