Cetaben

Cayman Chemical Item Number 10007171

Hexadecylamino-p-amino Benzoic Acid (CAS 55986-43-1)

Cetaben (CAS 55986-43-1)

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Description

The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity, characterized by reduction in serum triglyceride and cholesterol concentrations in rats.1 In male wistar rats, cetaben increased the activity of all peroxisomal enzymes examined in liver and kidney, whereas clofibrate showed a varied regulatory pattern.2 In addition to its effects on peroxisomes, cetaben inhibits cholesterol synthesis in the human hepatoma HepG2 cells resulting in reversible changes in Golgi morphology.3,4 It also blocked triglyceride synthesis by 99% and reduced cholesterol ester synthesis by >70% at a concentration of 50 µM in these same cells.4

1 Chandoga, J., Hampl, L., Turecký, L., et al. Cetaben is an exceptional type of peroxisome proliferator. Int J Biochem 26(5) 679-696 (1994).

2 Chandoga, J., Rojeková, I., Hampl, L., et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol 47(3) 515-519 (1994).

3 Kovacs, W., Walter, I., and Stangl, H. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma and HepG2 human hepatoblastoma cells. Histochem Cell Biol 115 509-519 (2001).

4 Kovacs, W., Schrader, M., Walter, I., et al. The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochem Cell Biol 122 95-109 (2004).

Synonyms
  • Hexadecylamino-p-amino Benzoic Acid
Formal Name 4-​(hexadecylamino)-​benzoic acid
CAS Number 55986-43-1
Molecular Formula C23H39NO2
Formula Weight 361.6
Formulation A crystalline solid
Purity ≥98%
λmax 224, 304 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCNC1=CC=C(C(O)​=O)​C=C1
InCHI Code
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​1S/C23H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-24-22-18-16-21(17-19-22)​23(25)​26/h16-19,24H,2-15,20H2,1H3,(H,25,26)​
InCHI Key
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QXWKHSSBFQDQPR-UHFFFAOYSA-N

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Cetaben is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $28.00 $0.00
10 mg $53.00 $0.00
50 mg $224.00 $0.00
100 mg $392.00 $0.00
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Pricing updated 2014-04-20. Prices are subject to change without notice.

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