Bicyclo Prostaglandin E2 Lipid Maps MS Standard

Cayman Chemical Item Number 10007213

Bicyclo PGE2 (CAS 74158-09-1)

Bicyclo Prostaglandin E2 Lipid Maps MS Standard (CAS 74158-09-1)

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Description

Bicyclo prostaglandin E2 (bicyclo PGE2) is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE21 found in human plasma at a median level of 20-25 pg/ml.2 Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify it as bicyclo PGE2 to estimate PGE2 biosynthesis or metabolism in vivo.3,4

1 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

3 Murphy, R.C., and Fitzgerald, G.A. Current approaches to estimation of eicosanoid formation in vivo. Adv Prostaglandin Thromboxane Leukot Res 22 341-348 (1994).

4 Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Synonyms
  • Bicyclo PGE2
Formal Name 11-​deoxy-​13,​14-​dihydro-​15-​keto-​11β,​15ξ-​cycloprostaglandin E2
CAS Number 74158-09-1
Molecular Formula C20H30O4
Formula Weight 336.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCC[C@@H]​1C(=O)​CC[C@@H]​2C(CCCCCCC(=O)​O)​C(=O)​C[C@H]​12

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Size Price Quantity Subtotal
1 mg $71.00 $0.00
5 mg $320.00 $0.00
10 mg $568.00 $0.00
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Pricing updated 2014-04-23. Prices are subject to change without notice.

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Related Products

13,14-dihydro-15-keto Prostaglandin E2
Bicyclo Prostaglandin E2

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