Thromboxane B2 Lipid Maps MS Standard

Cayman Chemical Item Number 10007237

TXB2 (CAS 54397-85-2)

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Description

Thromboxane B2 (TXB2) is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1 Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis,2 while measurement of 11-dehydro and 2,3-dinor TX metabolites gives the best estimate of systemic TXA2 secretion.3,4

1. Needleman, P., Moncada, S., Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261 558-560 (1976).

2. Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv Prostaglandin Thromboxane Leukot Res 11 493-498 (1983).

3. Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).

4. Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).

Synonyms
  • TXB2
Formal Name 9α,​11,​15S-​trihydroxythromba-​5Z,​13E-​dien-​1-​oic acid
CAS Number 54397-85-2
Molecular Formula C20H34O6
Formula Weight 370.5
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1OC(O)​CC(O)​C1C/C=C\CCCC(=O)​O

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Size Price Quantity Subtotal
1 mg $55.00 $0.00
5 mg $248.00 $0.00
10 mg $440.00 $0.00
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Related Products

11-dehydro Thromboxane B2
11-dehydro Thromboxane B2-d4
2,3-dinor Thromboxane B2
Thromboxane B2
Thromboxane B2-d4
Thromboxane B2 Quant-PAK
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