11-dehydro Thromboxane B2 Lipid Maps MS Standard

Cayman Chemical Item Number 10007239

11-keto TXB2; 11-dehydro TXB2 (CAS 67910-12-7)

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Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis.1,2,3,4 The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.2,3,4 Urinary concentrations of 11-dehydro TXB2 are approximately 30-70 ng/mmol creatinine.5,6

1. Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

2. Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

3. Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb Res 63 331-341 (1991).

4. Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 83 5861-5865 (1986).

5. Lellouche, F., Fradin, A., FitzGerald, G., et al. Enzyme immunoassay measurement of the urinary metabolites of thromboxane A2 and prostacyclin. Prostaglandins 40 297-310 (1990).

6. Perneby, C., Granström, E., Beck, O., et al. Optimization of an enzyme immunoassay for 11-dehydro-thromboxane B2 in urine: Comparison with GC-MS. Thromb Res 96 427-436 (1999).

  • 11-keto TXB2
  • 11-dehydro TXB2
Formal Name 9α,​15S-​dihydroxy-​11-​oxothromba-​5Z,​13E-​dien-​1-​oic acid
CAS Number 67910-12-7
Molecular Formula C20H32O6
Formula Weight 368.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
100 µg $139.00 $0.00
250 µg $330.00 $0.00
500 µg $626.00 $0.00
1 mg $1,112.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-28. Prices are subject to change without notice.

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