12-OxoETE Lipid Maps MS Standard

Cayman Chemical Item Number 10007249

12-KETE (CAS 108437-64-5)

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12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid.1,2 Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE.1,3 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via an Leukotriene B4 receptor or a common activation sequence.4

1. Falgueyret, J., Leblanc, Y., and Riendeau, D. Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETE. FEBS Lett 262 197-200 (1990).

2. Fruteau De Laclos, B., Maclouf, J., Poubelle, P., et al. Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid. Prostaglandins 33 315-337 (1987).

3. Falgueyret, J., Leblanc, Y., Rokach, J., et al. NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. Biochem Biophys Res Commun 156 1083-1089 (1988).

4. Naccache, P.H., Leblanc, Y., Rokach, J., et al. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: Evidence for the involvement of the leukotriene B4 receptor. Biochim Biophys Acta 1133 102-106 (1991).

  • 12-KETE
Formal Name 12-​oxo-​5Z,​8Z,​10E,​14Z-​eicosatetraenoic acid
CAS Number 108437-64-5
Molecular Formula C20H30O3
Formula Weight 318.5
Formulation A solution in ethanol
Purity ≥90%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
25 µg $116.00 $0.00
50 µg $220.00 $0.00
100 µg $418.00 $0.00
250 µg $928.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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