12(S)-HHTrE Lipid Maps MS Standard

Cayman Chemical Item Number 10007250

12-HHT (CAS 54397-84-1)

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12(S)-HHTrE is an unusual product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of the human platelet.1 It is biosynthesized by thromboxane (TX) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. The biological role of 12(S)-HHTrE is uncertain. It is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.2

1. Diczfalusy, U., Falardeau, P., and Hammarström, S. Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase. FEBS Lett 84 271-274 (1977).

2. Liu, Y., Yoden, K., Shen, R., et al. 12-L-Hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochem Biophys Res Commun 129 268-274 (1985).

  • 12-HHT
Formal Name 12S-​hydroxy-​5Z,​8E,​10E-​heptadecatrienoic acid
CAS Number 54397-84-1
Molecular Formula C17H28O3
Formula Weight 280.4
Formulation A solution in ethanol
Purity ≥97%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
25 µg $109.00 $0.00
50 µg $207.00 $0.00
100 µg $392.00 $0.00
250 µg $872.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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