9-Thiastearic Acid

Cayman Chemical Item Number 10007417

(CAS 106689-24-1)

9-Thiastearic Acid (CAS 106689-24-1)

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Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.1,2 9-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.3 This activity is associated with a hypolipidemic effect, making this 9-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

1 Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochem Pharmacol 51 751-758 (1996).

2 Pascal, R.A., and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. J Lipid Res 27 221-224 (1986).

3 Høvik, K.E., Spydevold ØS, and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochim Biophys Acta 1349 251-256 (1997).

Formal Name 8-​(nonylthio)-​octanoic acid
CAS Number 106689-24-1
Molecular Formula C17H34O2S
Formula Weight 302.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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9-Thiastearic Acid is available in the following screening library:

Size Price Quantity Subtotal
5 mg $33.00 $0.00
10 mg $63.00 $0.00
50 mg $264.00 $0.00
100 mg $462.00 $0.00
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Pricing updated 2014-04-21. Prices are subject to change without notice.

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