(S)-H-1152 (hydrochloride) (CAS 451462-58-1) (Inchi key BFOPDSJOLUQULZ-GXKRWWSZSA-N) || Cayman Chemical | Supplier
(S)-H-1152 (hydrochloride)
Item № 10007653
CAS № 451462-58-1
Purity ≥95%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
500 µg $28.00 $0.00
1 mg $53.00 $0.00
5 mg $224.00 $0.00
10 mg $392.00 $0.00

Pricing updated 2015-08-30. Prices are subject to change without notice.

Bulk Inquiry Form

X

Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Description

Rho kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM).12 It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM).2 H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).2 It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly,3 vasoconstriction,4 as well as spontaneously tonic smooth muscle5 and neurite extension.6

Download Product Insert Download Safety Data Sheet (SDS)

Related Products

Show all 7 Hide all but first 3

View Related Product Categories
Technical Information
Formal Name 5-​[[(2S)-​hexahydro-​2-​methyl-​1H-​1,​4-​diazepin-​1-​yl]sulfonyl]-​4-​methyl-​isoquinoline,​ dihydrochloride
CAS Number 451462-58-1
Molecular Formula C16H21N3O2S • 2HCl
Formula Weight 392.3
Purity ≥95%
Formulation A crystalline solid
λmax 216, 280, 328 nm
SMILES CC1=CN=CC2=C1C(S(N3CCCNC[C@@H]​3C)​(=O)​=O)​=CC=C2.Cl.Cl
InChI Code ​1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)​14)​22(20,21)​19-8-4-7-17-10-13(19)​2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
InChI Key BFOPDSJOLUQULZ-GXKRWWSZSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
Product Downloads

Download Product Insert 117 Kb PDF

Download Safety Data Sheet (SDS) 28 Kb PDF

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

Inserts
QC Sheets
Certificates of Analysis
GCMS Data
References & Background Reading
Product Description References

1. Sasaki, Y., Suzuki, M., and Hidaka, H. The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther 93 225-232 (2002).

2. Ikenoya, M., Hidaka, H., Hosoya, T., et al. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem 81 9-16 (2002).

3. Davies, S.L., Gibbons, C.E., Vizard, T., et al. Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids. Am J Physiol Cell Physiol 290 C1543-C1551 (2006).

4. Johnson, R.P., El-Yazbi, A.F., Takeya, K., et al. Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response. J Physiol 587(11) 2537-2553 (2009).

5. Rattan, S., and Patel, C.A. Selectivity of Rho kinase (ROCK) inhibitors in the spontaneously tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 294(3) G687-G693 (2008).

6. Fuentes, E.O., Leemhuis, J., Stark, G.B., et al. Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells. J Brachial Plex Peripher Nerve Inj 3(19) (2008).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...