PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)
Item № 10007762
Purity ≥98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
100 µg $50.00 $0.00
500 µg $225.00 $0.00
1 mg $400.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description
Synonyms
  • DHPI-4,5-P2
  • Phosphatidylinositol-4,5-bisphosphate C-6

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(4,5)-P2 (1,2-dihexanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

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Technical Information
Formal Name 1-​(1,​2-​dihexanoylphosphatidyl)inositol-​4,​5-​bisphosphate,​ trisodium salt
Synonyms
  • DHPI-4,5-P2
  • Phosphatidylinositol-4,5-bisphosphate C-6
Molecular Formula C21H38O19P3 · 3Na
Formula Weight 756.4
Purity ≥98%
Formulation A lyophilized powder
SMILES CCCCCC(OC[C@H]​(COP(O[C@@H]​1[C@H]​(O)​[C@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O]​)​(O)​=O)​[C@H]​1O)​([O-]​)​=O)​OC(CCCCC)​=O)​=O.[Na+]​.[Na]​.[Na+]​
InChI Code ​1S/C21H41O19P3.3Na/c1-3-5-7-9-14(22)​35-11-13(37-15(23)​10-8-6-4-2)​12-36-43(33,34)​40-19-16(24)​17(25)​20(38-41(27,28)​29)​21(18(19)​26)​39-42(30,31)​32;;;/h13,16-21,24-26H,3-12H2,1-2H3,(H,33,34)​(H2,27,28,29)​(H2,30,31,32)​;;;/q;3*+1/p-3/t13-,16-,17+,18+,1
InChI Key RLSRPPXCLVFTHW-JORWXVKOSA-K

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 109 Kb PDF

Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

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Inserts
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GCMS Data
References & Background Reading
Product Description References

1. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

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