PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)
Item № 10007764
Purity ≥98%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
100 µg $47.00 $0.00
500 µg $212.00 $0.00
1 mg $376.00 $0.00

Pricing updated 2015-09-05. Prices are subject to change without notice.

Bulk Inquiry Form

X

Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Description
Synonyms
  • DOPI-3,4,5-P3
  • Phosphatidylinositol-3,4,5-trisphosphate

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The short fatty acid chains of this analog give it different physical properties including high solubility in aqueous media compared to naturally occurring PtdIns-(3,4,5)-P3. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Phosphorylation of PtdIns-(4,5)-P2 by phosphoinositide (PI)-3-kinase initiates an intricate signalling cascade at the fore front of scientific research.3

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Products

Show all 34 Hide all but first 3

View Related Product Categories
Technical Information
Formal Name 1-​(1,​2-​dioctanoylphosphatidyl)inositol-​3,​4,​5-​trisphosphate,​ tetrasodium salt
Synonyms
  • DOPI-3,4,5-P3
  • Phosphatidylinositol-3,4,5-trisphosphate
Molecular Formula C25H46O22P4 · 4Na
Formula Weight 914.5
Purity ≥98%
Formulation A lyophilized powder
SMILES O=C(OC[C@H]​(COP(O[C@@H]​1[C@H]​(O)​[C@H]​(O[P+]​([O-]​)​(O)​=O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O]​)​(O)​=O)​[C@H]​1O)​([O-]​)​=O)​OC(CCCCCCC)​=O)​CCCCCCC.[Na+]​.[Na]​.[Na+]​.[Na]​
InChI Code ​1S/C25H50O22P4.4Na/c1-3-5-7-9-11-13-18(26)​41-15-17(43-19(27)​14-12-10-8-6-4-2)​16-42-51(39,40)​47-22-20(28)​23(44-48(30,31)​32)​25(46-50(36,37)​38)​24(21(22)​29)​45-49(33,34)​35;;;;/h17,20-25,28-29H,3-16H2,1-2H3,(H,39,40)​(H2,30,31,32)​(H2,33,34,35)​(H2,36,3
InChI Key HKEJKRRMHQTDJY-JQCOAGCCSA-J

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
Product Downloads

Download Product Insert 114 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

Inserts
QC Sheets
Certificates of Analysis
GCMS Data
References & Background Reading
Product Description References

1. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3. Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...