D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
Item № 10007783
CAS № 157542-47-7
Purity ≥98%
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100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description
Synonyms
  • Ins(1,4,5,6)-P4
  • 1,4,5,6-IP4

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.1 Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway.1 Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.2

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Technical Information
Formal Name D-​myo-​inositol-​1,​4,​5,​6-​tetra(hydrogen phosphate),​ tetrasodium salt
CAS Number 157542-47-7
Synonyms
  • Ins(1,4,5,6)-P4
  • 1,4,5,6-IP4
Molecular Formula C6H12O18P4 • 4Na
Formula Weight 588.0
Purity ≥98%
Formulation A lyophilized powder
SMILES O[C@@H]​1[C@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@@H]​1OP([O-]​)​(O)​=O.[Na+]​.[Na+]​.[Na+]​.[Na+]​
InChI Code ​1S/C6H16O18P4.4Na/c7-1-2(8)​4(22-26(12,13)​14)​6(24-28(18,19)​20)​5(23-27(15,16)​17)​3(1)​21-25(9,10)​11;;;;/h1-8H,(H2,9,10,11)​(H2,12,13,14)​(H2,15,16,17)​(H2,18,19,20)​;;;;/q;4*+1/p-4/t1-,2+,3?,4?,5?,6?;;;;
InChI Key DZJJWPAQUIBBLR-GUBBRYCUSA-J

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 91 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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Additional Information

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Inserts
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GCMS Data
References & Background Reading
Product Description References

1. Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci USA 94 14456-14460 (1997).

2. DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am J Physiol Cell Physiol 35 C429-C436 (1994).

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