11β-Hydroxysteroid Dehydrogenase || Cayman Chemical | Supplier
11β-Hydroxysteroid Dehydrogenase
Item № 10007815
Purity ≥95% estimated by SDS-PAGE
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CART TOTAL $0.00
100 µg $355.00 $0.00

Pricing updated 2015-08-30. Prices are subject to change without notice.

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Description

11-β-Hydroxysteroid dehydrogenase (11β-HSD) exists as two isozymes 11β-HSD1 and 11β-HSD2.1 Both isoforms are members of the short-chain dehydrogenase/reductase (SDRs) family.2 11β-HSD1 is a membrane-bound glycoprotein localized on the endoplasmic reticulum. The main catalytic domain of 11β-HSD1 lies within the lumen of the ER. A short five amino acid N-terminal region extends into the cytoplasm and is linked to the catalytic portion through a single transmembrane helix.1 11β-HSD1 is a relatively low affinity NADP-dependent enzyme with a bidirectional catalytic activity. The dehydrogenase reductase activity of 11β-HSD1 catalyzes the conversion of cortisol to cortisone. The primary function of 11β-HSD1 is the oxoreduction of cortisone to the active glucocorticoid cortisol.2 Cortisol is a steroid hormone essential for a variety of physiological and homeostatic functions.

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Technical Information
Purity ≥95% estimated by SDS-PAGE
Source active recombinant N-terminal His-tagged protein, expressed in E. coli
MW 31.4 kDa
Formulation A solution in 50 mM NaPO4, pH 7.6, containing 100 mM sodium chloride and 20% glycerol
UniProt Accession № P28845

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability 6 months
Product Downloads & Resources
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Download Product Insert 235 Kb PDF

Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Walker, E.A., Clark, A.M., Hewison, M., et al. Functional expression, characterization, and purification of the catalytic domain of human 11-β-hydroxysteroid dehydrogenase type 1. J Biol Chem 276(24) 21343-21350 (2001).

2. Blum, A., Martin, H., and Maser, E. Human 11β-hydroxysteroid dehydrogenase type 1 is enzymatically active in its nonglycosylated form. Biochem Biophys Res Commun 276 428-434 (2000).

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