8,11,14-Eicosatriynoic Acid

Cayman Chemical Item Number 10007900

8,11,14-ETI (CAS 34262-64-1)

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8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation.1 It inhibits cyclooxygenase (IC50 = 14 µM), human 12-lipoxygenase (IC50 = 0.46 µM), 5-lipoxygenase (IC50 = 25 µM) and the actions of slow-reacting substance of anaphylaxis (SRS-A) (IC50 = 10 µM).2,3

1. Goetz, J.M., Sprecher, H., Cornwell, D.G., et al. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins 12(2) 187-192 (1976).

2. Sun, F.F., McGuire, J.C., Morton, D.R., et al. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins 21(2) 333-343 (1981).

3. Jakschik, B.A., DiSantis, D.M., Sankarappa, S.K., et al. Modulation of leukotriene formation by various acetylenic acids. 127-135 (1982).

  • 8,11,14-ETI
Formal Name 8,​11,​14-​eicosatriynoic acid
CAS Number 34262-64-1
Molecular Formula C20H28O2
Formula Weight 300.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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8,11,14-Eicosatriynoic Acid is available in the following screening library:

Size Price Quantity Subtotal
1 mg $66.00 $0.00
5 mg $297.00 $0.00
10 mg $528.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

14(15)-EpEDE methyl ester
5,8,11-Eicosatriynoic Acid


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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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