SLF • Synthetic Ligand of FKBP (CAS 195513-96-3) (Inchi key IIDSDBBDZNDWCN-BJKOFHAPSA-N) || Cayman Chemical | Supplier
SLF
Item № 10007974
CAS № 195513-96-3
Purity ≥98%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
5 mg $74.00 $0.00
10 mg $141.00 $0.00
50 mg $592.00 $0.00
100 mg $992.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

Bulk Inquiry Form

X

Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Description
Synonyms
  • Synthetic Ligand of FKBP

FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation.1 Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin.2 By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment.2,3 For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.3

Download Product Insert Download Safety Data Sheet (SDS)

Related Products

Show all 4 Hide all but first 3

View Related Product Categories
View Screening Libraries with SLF
Technical Information
Formal Name (1R)-​1-​(3-​aminophenyl)-​3-​(3,​4-​dimethoxyphenyl)propyl ester-​1-​(3,​3-​dimethyl-​1,​2-​dioxopentyl)-​2S-​piperidinecarboxylic acid
CAS Number 195513-96-3
Synonyms
  • Synthetic Ligand of FKBP
Molecular Formula C30H40N2O6
Formula Weight 524.7
Purity ≥98%
Formulation A solution in ethanol
λmax 205, 232, 281 nm
SMILES COc1cc(CCC(OC(=O)​[C@@H]​2CCCCN2C(=O)​C(=O)​C(C)​(C)​CC)​c2cccc(N)​c2)​ccc1OC
InChI Code ​1S/C30H40N2O6/c1-6-30(2,3)​27(33)​28(34)​32-17-8-7-12-23(32)​29(35)​38-24(21-10-9-11-22(31)​19-21)​15-13-20-14-16-25(36-4)​26(18-20)​37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1
InChI Key IIDSDBBDZNDWCN-BJKOFHAPSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
Product Downloads

Download Product Insert 94 Kb PDF

Download Safety Data Sheet (SDS) 28 Kb PDF

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

Inserts
QC Sheets
Certificates of Analysis
GCMS Data
References & Background Reading
Product Description References

1. Dumont, F.J. FK506, An immunosuppressant targeting calcineurin function. Curr Med Chem 7 731-748 (2000).

2. Braun, P.D., Barglow, K.T., Lin, Y., et al. A bifunctional molecule that displays context-dependent cellular activity. J Am Chem Soc 125 7575-7580 (2003).

3. Amara, J.F., Clackson, T., Rivera, V.M., et al. A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci USA 94 10618-10623 (1997).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...