PtdIns-(4,5)-P2-biotin (sodium salt)

Cayman Chemical Item Number 10008159

Phosphatidylinositol-4,5-diphosphate C-8-biotin

PtdIns-(4,5)-P2-biotin (sodium salt)

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Description

The PtdIns phosphates play an important role in the generation and transduction of intracellular signals.1 PtdIns-(4,5)-P2-biotin is an affinity probe which allows the PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to serve as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

1 Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5 903-918 (2006).

Synonyms
  • Phosphatidylinositol-4,5-diphosphate C-8-biotin
Formal Name 1-​((1-​octanoyl-​N’-​biotinoyl-​1,​6-​diaminohexane-​2R-​octanoyl)phosphatidyl)inositol-​4,​5-​bisphosphate,​ trisodium salt
Molecular Formula C35H61N3O21P3S · 3Na
Formula Weight 1053.8
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(O)​[C@H]​(O)​[C@@H]​1OP([O-]​)​(OC[C@H]​(COC(CCCCCCCNC(CCCC[C@H]​2SC[C@@]​(N3[H]​)​([H]​)​[C@]​2([H]​)​N([H]​)​C3=O)​=O)​=O)​OC(CCCCCCC)​=O)​=O.[Na+]​.[Na+]​.[Na+]​
InCHI Code
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​1S/C35H64N3O21P3S.3Na/c1-2-3-4-6-10-17-27(41)​56-22(20-55-62(52,53)​59-32-29(42)​30(43)​33(57-60(46,47)​48)​34(31(32)​44)​58-61(49,50)​51)​19-54-26(40)​16-9-7-5-8-13-18-36-25(39)​15-12-11-14-24-28-23(21-63-24)​37-35(45)​38-28;;;/h22-24,28-34,42-44H,2-21H2,1H
InCHI Key
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USLRCVJGAGJDIV-WFWFDGKXSA-K

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Size Price Quantity Subtotal
10 µg $129.00 $0.00
25 µg $306.00 $0.00
50 µg $529.00 $0.00
100 µg $839.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2014-04-16. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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