PtdIns-(4,5)-P2-biotin (sodium salt)

Cayman Chemical Item Number 10008159

Phosphatidylinositol-4,5-diphosphate C-8-biotin

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The PtdIns phosphates play an important role in the generation and transduction of intracellular signals.1 PtdIns-(4,5)-P2-biotin is an affinity probe which allows the PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to serve as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

1. Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 5 903-918 (2006).

  • Phosphatidylinositol-4,5-diphosphate C-8-biotin
Formal Name 1-​((1-​octanoyl-​N’-​biotinoyl-​1,​6-​diaminohexane-​2R-​octanoyl)phosphatidyl)inositol-​4,​5-​bisphosphate,​ trisodium salt
Molecular Formula C35H61N3O21P3S · 3Na
Formula Weight 1053.8
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
10 µg $129.00 $0.00
25 µg $306.00 $0.00
50 µg $529.00 $0.00
100 µg $839.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-27. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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