9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester
Item № 10008333
CAS № 4175-47-7
Purity ≥98%
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1 mg $45.00 $0.00
5 mg $203.00 $0.00
10 mg $360.00 $0.00

Pricing updated 2016-02-05. Prices are subject to change without notice.

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  • Methyl α-eleostearate
  • α-ESA methyl ester

9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.1 α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.2 It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ.1 In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM.2 It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.3 α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

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Technical Information
Formal Name 9Z,11E,13E-octadecatrienoic acid, methyl ester
CAS Number 4175-47-7
  • Methyl α-eleostearate
  • α-ESA methyl ester
Molecular Formula C19H32O2
Formula Weight 292.5
Purity ≥98%
Formulation A solution in ethanol
λmax 261, 270, 281 nm
InChI Code 1S/C19H32O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21-2/h6-11H,3-5,12-18H2,1-2H3/b7-6+,9-8+,11-10-

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 112 Kb PDF

Download Safety Data Sheet (SDS) 31 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Yasui, Y., Hosokawa, M., Sahara, T., et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 75 113-119 (2005).

2. Tsuzuki, T., Tokuyama, Y., Igarashi, M., et al. Tumor growth suppression by a α-eleostearic acid, linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis 25(8) 1417-1425 (2004).

3. Mizushina, Y., Tsuzuki, T., Eitsuka, T., et al. Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases. Lipids 39(10) 977-983 (2004).

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