8-iso-17-phenyl trinor Prostaglandin F

Cayman Chemical Item Number 10008435

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8-iso-17-phenyl trinor Prostaglandin F (8-iso-17-phenyl trinor PGF) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF binding with a Ki of 1.1 nM.2 There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF.

1. Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F receptor. Biochem Pharmacol 38 2375-2381 (1989).

2. Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F receptors and the expression of the rat prostaglandin F receptor. FEBS Lett 355 317-325 (1994).

Formal Name 9α,​11α,​15S-​trihydroxy-​17-​phenyl-​18,​19,​20-​trinor-​(8β)-​prosta-​5Z,​13E-​dien-​1-​oic acid
Molecular Formula C23H32O5
Formula Weight 388.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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8-iso-17-phenyl trinor Prostaglandin F is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $138.00 $0.00
5 mg $621.00 $0.00
10 mg $1,104.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-02. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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