8-iso-17-phenyl trinor Prostaglandin F

Cayman Chemical Item Number 10008435

See more

Description

8-iso-17-phenyl trinor Prostaglandin F (8-iso-17-phenyl trinor PGF) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF binding with a Ki of 1.1 nM.2 There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF.

1. Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F receptor. Biochem Pharmacol 38 2375-2381 (1989).

2. Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F receptors and the expression of the rat prostaglandin F receptor. FEBS Lett 355 317-325 (1994).

Formal Name 9α,​11α,​15S-​trihydroxy-​17-​phenyl-​18,​19,​20-​trinor-​(8β)-​prosta-​5Z,​13E-​dien-​1-​oic acid
Molecular Formula C23H32O5
Formula Weight 388.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O[C@@H]​1[C@@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCC2=CC=CC=C2)​[C@H]​(O)​C1
InCHI Code
Copy InCHI code to clipboard
​1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)​14-15-20-19(21(25)​16-22(20)​26)​10-6-1-2-7-11-23(27)​28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)​/b6-1-,15-14+/t18-,19-,20+,21-,22+/m0/s1
InCHI Key
Copy InCHI key to clipboard
YFHHIZGZVLHBQZ-ASXHZHNKSA-N

Download free InCHI Key generation software

8-iso-17-phenyl trinor Prostaglandin F is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $138.00 $0.00
5 mg $621.00 $0.00
10 mg $1,104.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-02. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

17-phenyl trinor Prostaglandin F
17-phenyl trinor Prostaglandin F cyclohexyl amide
8-iso-17-phenyl trinor Prostaglandin F
8-iso Prostaglandin F
Show all 4 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...