D-myo-Inositol-1,2,5,6-tetraphosphate (sodium salt)

Cayman Chemical Item Number 10008444

Ins(1,2,5,6)P4 (sodium salt); 1,2,5,6-IP4 (sodium salt)

D-myo-Inositol-1,2,5,6-tetraphosphate (sodium salt)

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Description

D-myo-Inositol-1,2,5,6-tetraphosphate (Ins(1,2,5,6)P4) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.1,2,3. Ins(1,2,5,6)P4 binds to the murine Grp-1 PH domain with a Kd(apparent) of 0.18 µM, which is about 6.7-fold higher than for Ins(1,3,4,5)P4.4 It binds to rat heart membranes and significantly decreases heart rate in a pithed rat model.5

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998).

4 Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998).

5 Sun, X.X., Edvinsson, L., Yoo, H., et al. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol 25 696-704 (1995).

Synonyms
  • Ins(1,2,5,6)P4 (sodium salt)
  • 1,2,5,6-IP4 (sodium salt)
Formal Name D-​myo-​inositol-​1,​2,​5,​6-​tetra(dihydrogen phosphate),​ tetrasodium salt
Molecular Formula C6H12O18P4· 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@@H]​(O)​[C@@H]​(O[P+]​([O-]​)​(O)​=O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O]​)​(O)​=O)​[C@H]​1OP([O-]​)​([OH+]​)​=O.[Na+]​.[Na]​.[Na]​.[Na]​
InCHI Code
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​1S/C6H16O18P4.4Na/c7-1-2(8)​4(22-26(12,13)​14)​6(24-28(18,19)​20)​5(23-27(15,16)​17)​3(1)​21-25(9,10)​11;;;;/h1-8H,(H2,9,10,11)​(H2,12,13,14)​(H2,15,16,17)​(H2,18,19,20)​;;;;/q;4*+1/p-4/t1-,2-,3?,4?,5?,6?;;;;/m1..../s1
InCHI Key
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DZJJWPAQUIBBLR-SEPOYWDNSA-J

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Size Price Quantity Subtotal
100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2014-04-18. Prices are subject to change without notice.

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