3-methoxy Limaprost

Cayman Chemical Item Number 10008445

3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1; 3-methoxy-2,3-dihydro-Limaprost (CAS 1224443-96-2)

3-methoxy Limaprost (CAS 1224443-96-2)

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Description

Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro.1 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost.

1 Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Synonyms
  • 3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1
  • 3-methoxy-2,3-dihydro-Limaprost
Formal Name 3-​methoxy-​11α,​15S-​dihydroxy-​17S,​20-​dimethyl-​9-​oxo-​prosta-​13E-​en-​1-​oic acid
CAS Number 1224443-96-2
Molecular Formula C23H40O6
Formula Weight 412.6
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​([C@H]​(/C=C/[C@@H]​(O)​C[C@@H]​(C)​CCCC)​[C@H]​1CCCCC(OC)​CC(O)​=O)​CC1=O
InCHI Code
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​1S/C23H40O6/c1-4-5-8-16(2)​13-17(24)​11-12-20-19(21(25)​15-22(20)​26)​10-7-6-9-18(29-3)​14-23(27)​28/h11-12,16-20,22,24,26H,4-10,13-15H2,1-3H3,(H,27,28)​/b12-11+/t16-,17+,18?,19+,20+,22+/m0/s1
InCHI Key
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CQMVTHTYLSWGRI-HMHRGJHKSA-N

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3-methoxy Limaprost is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-21. Prices are subject to change without notice.

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Related Products

Limaprost
Prostaglandin E1

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