3-methoxy Limaprost

Cayman Chemical Item Number 10008445

3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1; 3-methoxy-2,3-dihydro-Limaprost (CAS 1224443-96-2)

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Description

Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro.1 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost.

1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Synonyms
  • 3-methoxy-17α,20-dimethyl-Δ2-Prostaglandin E1
  • 3-methoxy-2,3-dihydro-Limaprost
Formal Name 3-​methoxy-​11α,​15S-​dihydroxy-​17S,​20-​dimethyl-​9-​oxo-​prosta-​13E-​en-​1-​oic acid
CAS Number 1224443-96-2
Molecular Formula C23H40O6
Formula Weight 412.6
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​([C@H]​(/C=C/[C@@H]​(O)​C[C@@H]​(C)​CCCC)​[C@H]​1CCCCC(OC)​CC(O)​=O)​CC1=O
InCHI Code
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​1S/C23H40O6/c1-4-5-8-16(2)​13-17(24)​11-12-20-19(21(25)​15-22(20)​26)​10-7-6-9-18(29-3)​14-23(27)​28/h11-12,16-20,22,24,26H,4-10,13-15H2,1-3H3,(H,27,28)​/b12-11+/t16-,17+,18?,19+,20+,22+/m0/s1
InCHI Key
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CQMVTHTYLSWGRI-HMHRGJHKSA-N

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3-methoxy Limaprost is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
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Pricing updated 2015-04-26. Prices are subject to change without notice.

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Related Products

Limaprost
Prostaglandin E1

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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