D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt)

Cayman Chemical Item Number 10008451

Ins(1,2,4,5)P4 (sodium salt); 1,2,4,5-IP4 (sodium salt)

D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt)

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Description

D-myo-Inositol-1,2,4,5-tetraphosphate (Ins(1,2,4,5)P4) is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals.1,2,3. Ins(1,2,4,5)P4 exhibits agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells where it induces Ca2+ mobilization with an ED50 value of 0.22 µM, making it nearly equipotent to Ins(1,4,5)P3 (EC50 = 0.1 µM) in the same assay.4

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998).

4 Burford, N.T., Nahorski, S.R., Chung, S., et al. Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor. Cell Calcium 21 301-310 (1997).

Synonyms
  • Ins(1,2,4,5)P4 (sodium salt)
  • 1,2,4,5-IP4 (sodium salt)
Formal Name D-​myo-​Inositol-​1,​2,​4,​5-​tetrakis(dihydrogen phosphate),​ tetrasodium salt
Molecular Formula C6H12O18P4· 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​1OP([O-]​)​(O)​=O.[Na+]​.[Na+]​.[Na+]​.[Na+]​
InCHI Code
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​1S/C6H16O18P4.4Na/c7-1-3(21-25(9,10)​11)​5(23-27(15,16)​17)​2(8)​6(24-28(18,19)​20)​4(1)​22-26(12,13)​14;;;;/h1-8H,(H2,9,10,11)​(H2,12,13,14)​(H2,15,16,17)​(H2,18,19,20)​;;;;/q;4*+1/p-4/t1-,2-,3?,4?,5?,6?;;;;
InCHI Key
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GPEDWSWFXATPAL-ZGXJPNOWSA-J

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D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00
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Pricing updated 2014-04-23. Prices are subject to change without notice.

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