15-keto Iloprost

Cayman Chemical Item Number 10008616

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Description

15-keto Iloprost is the C-15 oxidized derivative of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.1 There are no published studies of the pharmacological properties of 15-keto iloprost.

1. Schrör, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn Schmiedebergs Arch Pharmacol 316 252-255 (1981).

Formal Name 6,​9α-​methylene-​11α-​hydroxy-​15-​keto-​16-​methyl-​prosta-​5E,​13E-​dien-​18-​yn-​1-​oic acid
Molecular Formula C22H30O4
Formula Weight 358.5
Formulation A solution in methyl acetate
Purity ≥97%
λmax 236 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1C[C@H]​2[C@H]​(C/C(C2)​=C/CCCC(O)​=O)​[C@H]​1/C=C/C(C(C)​CC#CC)​=O
InCHI Code
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​1S/C22H30O4/c1-3-4-7-15(2)​20(23)​11-10-18-19-13-16(8-5-6-9-22(25)​26)​12-17(19)​14-21(18)​24/h8,10-11,15,17-19,21,24H,5-7,9,12-14H2,1-2H3,(H,25,26)​/b11-10+,16-8+/t15?,17-,18+,19-,21+/m0/s1
InCHI Key
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LDICATDQJSBQOX-JNSFOOLWSA-N

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15-keto Iloprost is available in the following screening library:

Size Price Quantity Subtotal
500 µg $107.00 $0.00
1 mg $203.00 $0.00
5 mg $856.00 $0.00
10 mg $1,498.00 $0.00
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Cart Total $0.00

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Pricing updated 2015-04-01. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

15(R)-Iloprost
Cicaprost
Iloprost

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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