13,14-dihydro-15-keto Prostaglandin J2

Cayman Chemical Item Number 10008840

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Description

Various biological properties exist for both prostaglandin J2 (PGJ2) and its metabolites such as inhibition of platelet aggregation, antitumor, and antiviral activity.1,2 13,14-dihydro-15-keto PGJ2 is the dehydration product of 13,14-dihydro-15-keto PGD2 and is a presumed metabolite of PGJ2 via the 15-hydroxy PG dehydrogenase pathway. There are no published studies of the pharmacological properties or the formation of 13,14-dihydro-15-keto PGJ2 in vivo.

1. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

2. Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

Formal Name 11,​15-​dioxo-​prosta-​5Z,​9-​en-​1-​oic acid
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity ≥97%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1C=C[C@H]​(C/C=C\CCCC(O)​=O)​[C@H]​1CCC(CCCCC)​=O
InCHI Code
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​1S/C20H30O4/c1-2-3-6-10-17(21)​13-14-18-16(12-15-19(18)​22)​9-7-4-5-8-11-20(23)​24/h4,7,12,15-16,18H,2-3,5-6,8-11,13-14H2,1H3,(H,23,24)​/b7-4-/t16-,18+/m0/s1
InCHI Key
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GCYWVCQBMLYQGZ-BFVRRIQPSA-N

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13,14-dihydro-15-keto Prostaglandin J2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $99.00 $0.00
1 mg $188.00 $0.00
5 mg $792.00 $0.00
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Pricing updated 2015-04-27. Prices are subject to change without notice.

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Related Products

Prostaglandin J2
Δ12-Prostaglandin J2

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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