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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

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Propylpyrazole Triol

Cayman Chemical Item Number 10008841

PPT (CAS 263717-53-9)

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Description

Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.1,2 In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.3

1. Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J Med Chem 43 4934-4947 (2000).

2. Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

3. Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol 289 H2039-H2047 (2005).

Synonyms
  • PPT
Formal Name 4,​4',​4''-​(4-​propyl-​1H-​pyrazole-​1,​3,​5-​triyl)tris-​phenol
CAS Number 263717-53-9
Molecular Formula C24H22N2O3
Formula Weight 386.4
Formulation A crystalline solid
Purity ≥98%
λmax 255 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC=C(C=C1)​N2C(C3=CC=C(O)​C=C3)​=C(CCC)​C(C4=CC=C(O)​C=C4)​=N2
InCHI Code
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​1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)​11-5-16)​25-26(18-8-14-21(29)​15-9-18)​24(22)​17-6-12-20(28)​13-7-17/h4-15,27-29H,2-3H2,1H3
InCHI Key
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IOTXSIGGFRQYKW-UHFFFAOYSA-N

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Propylpyrazole Triol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
25 mg $280.00 $0.00
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Cart Total $0.00

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Pricing updated 2015-02-28. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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