JWH 015

Cayman Chemical Item Number 10009018

(CAS 155471-08-2)

JWH 015 (CAS 155471-08-2)

Looking for JWH 015 RM or JWH 015 CRM?

See more

Description

JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively.1 Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis (MS), treatment with WIN 55,212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease.2 JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.3

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2 Arévalo-Martín Á, Vela, J.M., Molina-Holgado, E., et al. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J Neurosci 23(7) 2511-2516 (2003).

3 Enrhart, J., Obregon, D., Mori, T., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29-41 (2005).

Formal Name (2-​methyl-​1-​propyl-​1H-​indol-​3-​yl)-​1-​naphthalenyl-​methanone
CAS Number 155471-08-2
Molecular Formula C23H21NO
Formula Weight 327.4
Formulation A crystalline solid
Purity ≥95%
λmax 219, 320 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCn1c(C)​c(c2ccccc12)​C(=O)​c1cccc2ccccc12
InCHI Code
Copy InCHI code to clipboard
​1S/C23H21NO/c1-3-15-24-16(2)​22(20-12-6-7-14-21(20)​24)​23(25)​19-13-8-10-17-9-4-5-11-18(17)​19/h4-14H,3,15H2,1-2H3
InCHI Key
Copy InCHI key to clipboard
LJSBBBWQTLXQEN-UHFFFAOYSA-N

Download free InCHI Key generation software

JWH 015 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $140.00 $0.00
25 mg $298.00 $0.00
50 mg $525.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-23. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

JWH 015 CRM
JWH 015-d7
JWH 015 RM
JWH 081 4-hydroxynaphthyl metabolite
JWH 146
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · Experimental Biology 2014 · San Diego, California · April 26-30, 2014 · Booth 323 Join us! · ASPET Symposium 2014: Scientists versus Street Chemists: The Toxicity of Designer Marijuana · San Diego, California · April 30, 2014
Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?