JWH 015
Item № 10009018
CAS № 155471-08-2
Purity ≥95%
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10 mg $140.00 $0.00
25 mg $298.00 $0.00
50 mg $525.00 $0.00

Pricing updated 2015-09-04. Prices are subject to change without notice.

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Description

JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively.1 Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis (MS), treatment with WIN 55,212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease.2 JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.3

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Technical Information
Formal Name (2-​methyl-​1-​propyl-​1H-​indol-​3-​yl)-​1-​naphthalenyl-​methanone
CAS Number 155471-08-2
Molecular Formula C23H21NO
Formula Weight 327.4
Purity ≥95%
Formulation A crystalline solid
λmax 219, 320 nm
SMILES CCCn1c(C)​c(c2ccccc12)​C(=O)​c1cccc2ccccc12
InChI Code ​1S/C23H21NO/c1-3-15-24-16(2)​22(20-12-6-7-14-21(20)​24)​23(25)​19-13-8-10-17-9-4-5-11-18(17)​19/h4-14H,3,15H2,1-2H3
InChI Key LJSBBBWQTLXQEN-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2. Arévalo-Martín Á, Vela, J.M., Molina-Holgado, E., et al. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J Neurosci 23(7) 2511-2516 (2003).

3. Enrhart, J., Obregon, D., Mori, T., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29-41 (2005).

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