JWH 015

Cayman Chemical Item Number 10009018

(CAS 155471-08-2)

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JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively.1 Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis (MS), treatment with WIN 55,212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease.2 JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.3

1. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2. Arévalo-Martín Á, Vela, J.M., Molina-Holgado, E., et al. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J Neurosci 23(7) 2511-2516 (2003).

3. Enrhart, J., Obregon, D., Mori, T., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29-41 (2005).

Formal Name (2-​methyl-​1-​propyl-​1H-​indol-​3-​yl)-​1-​naphthalenyl-​methanone
CAS Number 155471-08-2
Molecular Formula C23H21NO
Formula Weight 327.4
Formulation A crystalline solid
Purity ≥95%
λmax 219, 320 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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JWH 015 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $140.00 $0.00
25 mg $298.00 $0.00
50 mg $525.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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