Bezafibrate

Cayman Chemical Item Number 10009145

Benzofibrate; BM 15075; Bezalip; Bezatrol; Difaterol (CAS 41859-67-0)

Bezafibrate (CAS 41859-67-0)

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Description

Bezafibrate is a well established pan-peroxisome proliferator-activated receptor (pan-PPAR) activator. This fibrate drug has over 25 years of therapeutic use with a good safety profile. The fibrate class of drugs are generally known as PPARα agonists, but bezafibrate appears to activate PPARδ and PPARγ as well. Bezafibrate activates human PPARα, PPARδ, and PPARγ with EC50 values of 50, 20, and 60 µM, respectively, in a cell-based transcription assay.1 Bezafibrate is used to treat hyperlipidemia. It helps lower low-density lipoprotein cholesterol and triglycerides while raising high-density lipoprotein cholesterol levels. It also improves insulin sensitivity and reduces blood glucose levels, which in combination with the cholesterol effects significantly lowers the incidence of cardiovascular events and development of diabetes in patients with features of metabolic syndrome.2

1 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

2 Tenenbaum, A., Motro, M., and Fisman, E.Z. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons. Cardiovasc Diabetol 4(14) 1-5 (2005).

Synonyms
  • Benzofibrate
  • BM 15075
  • Bezalip
  • Bezatrol
  • Difaterol
Formal Name 2-​[4-​[2-​[(4-​chlorobenzoyl)amino]ethyl]phenoxy]-​2-​methyl-​propanoic acid
CAS Number 41859-67-0
Molecular Formula C19H20ClNO4
Formula Weight 361.8
Formulation A crystalline solid
Purity ≥98%
λmax 229 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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ClC1=CC=C(C(NCCC2=CC=C(OC(C)​(C)​C(O)​=O)​C=C2)​=O)​C=C1
InCHI Code
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​1S/C19H20ClNO4/c1-19(2,18(23)​24)​25-16-9-3-13(4-10-16)​11-12-21-17(22)​14-5-7-15(20)​8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)​(H,23,24)​
InCHI Key
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IIBYAHWJQTYFKB-UHFFFAOYSA-N

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Bezafibrate is available in the following screening library:

Size Price Quantity Subtotal
500 mg $9.00 $0.00
1 g $17.00 $0.00
5 g $72.00 $0.00
10 g $126.00 $0.00
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Pricing updated 2014-04-19. Prices are subject to change without notice.

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