Valinomycin
Item № 10009152
CAS № 2001-95-8
Purity ≥95%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
5 mg $15.00 $0.00
10 mg $29.00 $0.00
25 mg $68.00 $0.00
50 mg $120.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

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Description
Synonyms
  • NSC 122023

Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore antibiotic that is isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. 1 Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.

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Technical Information
Formal Name 3,​6,​9,​15,​18,​21,​27,​30,​33-​nonaisopropyl-​12,​24,​36-​trimethyl-​1,​7,​13,​19,​25,​31-​hexaoxa-​4,​10,​16,​22,​28,​34-​hexaaza-​cyclohexatriacontane-​2,​5,​8,​11,​14,​17,​20,​23,​26,​29,​32,​35-​dodecaone
CAS Number 2001-95-8
Synonyms
  • NSC 122023
Molecular Formula C54H90N6O18
Formula Weight 1111.3
Purity ≥95%
Formulation A crystalline solid
SMILES CC(C)​[C@H]​1OC(=O)​C(NC(=O)​[C@H]​(C)​OC(=O)​[C@H]​(NC(=O)​C(OC(=O)​C(NC(=O)​C(C)​OC(=O)​C(NC(=O)​[C@H]​(OC(=O)​[C@@H]​(NC(=O)​C(C)​OC(=O)​[C@H]​(NC1=O)​C(C)​C)​C(C)​C)​C(C)​C)​C(C)​C)​C(C)​C)​C(C)​C)​C(C)​C)​C(C)​C
InChI Code ​1S/C54H90N6O18/c1-22(2)​34-49(67)​73-31(19)​43(61)​55-38(26(9)​10)​53(71)​77-41(29(15)​16)​47(65)​59-36(24(5)​6)​51(69)​75-33(21)​45(63)​57-39(27(11)​12)​54(72)​78-42(30(17)​18)​48(66)​60-35(23(3)​4)​50(68)​74-32(20)​44(62)​56-37(25(7)​8)​52(70)​76-40(28(13)​14)​46(64)​58-34/
InChI Key FCFNRCROJUBPLU-CVZFCLRKSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 117 Kb PDF

Download Safety Data Sheet (SDS) 27 Kb PDF

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Additional Information

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Inserts
QC Sheets
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GCMS Data
References & Background Reading
Product Description References

1. Abdalah, R., Wei, L., Francis, K., et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett 405 68-73 (2006).

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