SC-1

Cayman Chemical Item Number 10009557

Pluripotin (CAS 839707-37-8)

SC-1 (CAS 839707-37-8)

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Description

The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.1 The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.1 Inhibition of Ras-GAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.

1 Chen, S., Do, J.T., Zhang, Q., et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA 103(46) 17266-17271 (2006).

Synonyms
  • Pluripotin
Formal Name N-​(3-​(7-​(1,​3-​dimethyl-​1H-​pyrazol-​5-​ylamino)-​1-​methyl-​2-​oxo-​1,​2-​dihydropyrimido[4,​5-​d]pyrimidin-​3(4H)-​yl)-​4-​methylphenyl)-​3-​(trifluoromethyl)benzamide
CAS Number 839707-37-8
Molecular Formula C27H25F3N8O2
Formula Weight 550.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Cc1nn(C)​c(Nc2ncc3CN(c4cc(ccc4C)​NC(=O)​c4cccc(c4)​C(F)​(F)​F)​C(=O)​N(C)​c3n2)​c1
InCHI Code
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​1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)​17-6-5-7-19(11-17)​27(28,29)​30)​12-21(15)​38-14-18-13-31-25(34-23(18)​36(3)​26(38)​40)​33-22-10-16(2)​35-37(22)​4/h5-13H,14H2,1-4H3,(H,32,39)​(H,31,33,34)​
InCHI Key
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NBZFRTJWEIHFPF-UHFFFAOYSA-N

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SC-1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $78.00 $0.00
5 mg $351.00 $0.00
10 mg $624.00 $0.00
25 mg $1,365.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-18. Prices are subject to change without notice.

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