Item № 10009634
CAS № 483367-10-8
Purity ≥98%
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1 mg $22.00 $0.00
5 mg $99.00 $0.00
10 mg $176.00 $0.00
25 mg $385.00 $0.00

Pricing updated 2015-11-28. Prices are subject to change without notice.

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Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.1,2 The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.1 Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.3,4

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Technical Information
Formal Name 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
CAS Number 483367-10-8
Molecular Formula C31H32N6O2
Formula Weight 520.6
Purity ≥98%
Formulation A crystalline solid
λmax 221, 316 nm
SMILES O1CCN(CC1)c1ccc(cc1)Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1
InChI Code 1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Wu, X., Ding, Q., Gray, N.S., et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc 124 14520-14521 (2002).

2. Beloti, M.M., Bellesini, L.S., and Rosa, A.L. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int 29(7) 537-541 (2005).

3. Wu, X., Walker, J., Zhang, J., et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11 1229-1238 (2004).

4. Sinha, S., and Chen, J.K. Purmorphamine activates the hedgehog pathway by targeting smoothened. Nat Chem Biol 2(1) 29-30 (2006).

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