Cayman Chemical Item Number 10009661

(CAS 925891-74-3)

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Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.1,2 N-Octadecyl-N'-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.3,2 At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N'-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.3

1. de Fonseca, F.R., Navarro, M., Gómez, R., et al. An anorexic lipid mediator regulated by feeding. Nature 414 209-212 (2001).

2. Fu, J., Gaetani, S., Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425 90-93 (2003).

3. Cano, C., Pavón, J., Serrano, A., et al. Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARα activation. J Med Chem 50 389-393 (2007).

Formal Name N-​octadecyl-​N'-​propyl-​sulfamide
CAS Number 925891-74-3
Molecular Formula C21H46N2O2S
Formula Weight 390.7
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
5 mg $61.00 $0.00
10 mg $116.00 $0.00
25 mg $275.00 $0.00
50 mg $488.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


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