EX-527

Cayman Chemical Item Number 10009798

(CAS 49843-98-3)

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Description

Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM).1 It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.2

1. Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

2. Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

Formal Name 6-​chloro-​2,​3,​4,​9-​tetrahydro-​1H-​carbazole-​1-​carboxamide
CAS Number 49843-98-3
Molecular Formula C13H13ClN2O
Formula Weight 248.7
Formulation A crystalline solid
Purity ≥98%
λmax 233, 291 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(=O)​C1CCCc2c1[nH]​c1ccc(Cl)​cc21
InCHI Code
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​1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)​8-2-1-3-9(13(15)​17)​12(8)​16-11/h4-6,9,16H,1-3H2,(H2,15,17)​
InCHI Key
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FUZYTVDVLBBXDL-UHFFFAOYSA-N

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EX-527 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $46.00 $0.00
10 mg $75.00 $0.00
25 mg $163.00 $0.00
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Pricing updated 2015-05-29. Prices are subject to change without notice.

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