EX-527
Item № 10009798
CAS № 49843-98-3
Purity ≥98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $25.00 $0.00
5 mg $46.00 $0.00
10 mg $75.00 $0.00
25 mg $163.00 $0.00

Pricing updated 2015-08-27. Prices are subject to change without notice.

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Description

Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM).1 It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.2

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Technical Information
Formal Name 6-​chloro-​2,​3,​4,​9-​tetrahydro-​1H-​carbazole-​1-​carboxamide
CAS Number 49843-98-3
Molecular Formula C13H13ClN2O
Formula Weight 248.7
Purity ≥98%
Formulation A crystalline solid
λmax 233, 291 nm
SMILES NC(=O)​C1CCCc2c1[nH]​c1ccc(Cl)​cc21
InChI Code ​1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)​8-2-1-3-9(13(15)​17)​12(8)​16-11/h4-6,9,16H,1-3H2,(H2,15,17)​
InChI Key FUZYTVDVLBBXDL-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Safety Data Sheet (SDS) 25 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

2. Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

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