EX-527

Cayman Chemical Item Number 10009798

(CAS 49843-98-3)

EX-527 (CAS 49843-98-3)

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Description

Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM).1 It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.2

1 Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).

2 Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

Formal Name 6-​chloro-​2,​3,​4,​9-​tetrahydro-​1H-​carbazole-​1-​carboxamide
CAS Number 49843-98-3
Molecular Formula C13H13ClN2O
Formula Weight 248.7
Formulation A crystalline solid
Purity ≥98%
λmax 233, 291 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(=O)​C1CCCc2c1[nH]​c1ccc(Cl)​cc21
InCHI Code
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​1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)​8-2-1-3-9(13(15)​17)​12(8)​16-11/h4-6,9,16H,1-3H2,(H2,15,17)​
InCHI Key
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FUZYTVDVLBBXDL-UHFFFAOYSA-N

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EX-527 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $17.00 $0.00
5 mg $77.00 $0.00
10 mg $136.00 $0.00
25 mg $298.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-16. Prices are subject to change without notice.

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