GW 590735 Exclusive

Cayman Chemical Item Number 10009880

(CAS 622402-22-6)

GW 590735 (CAS 622402-22-6)

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Description

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression of a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

1 Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

Formal Name 2-​methyl-​2-​(4-​((4-​methyl-​2-​(4-​(trifluoromethyl)phenyl)thiazole-​5-​carboxamido)methyl)phenoxy)propanoic acid
CAS Number 622402-22-6
Molecular Formula C23H21F3N2O4S
Formula Weight 478.5
Formulation A crystalline solid
Purity ≥98%
λmax 224, 311 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NCc1ccc(cc1)​OC(C)​(C)​C(=O)​O)​c1sc(nc1C)​c1ccc(cc1)​C(F)​(F)​F
InCHI Code
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​1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)​15-6-8-16(9-7-15)​23(24,25)​26)​19(29)​27-12-14-4-10-17(11-5-14)​32-22(2,3)​21(30)​31/h4-11H,12H2,1-3H3,(H,27,29)​(H,30,31)​
InCHI Key
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ILUPZUOBHCUBKB-UHFFFAOYSA-N

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GW 590735 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-24. Prices are subject to change without notice.

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