GW 590735 Exclusive

Cayman Chemical Item Number 10009880

(CAS 622402-22-6)

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Description

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

1. Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

Formal Name 2-​methyl-​2-​(4-​((4-​methyl-​2-​(4-​(trifluoromethyl)phenyl)thiazole-​5-​carboxamido)methyl)phenoxy)propanoic acid
CAS Number 622402-22-6
Molecular Formula C23H21F3N2O4S
Formula Weight 478.5
Formulation A crystalline solid
Purity ≥98%
λmax 224, 311 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NCc1ccc(cc1)​OC(C)​(C)​C(=O)​O)​c1sc(nc1C)​c1ccc(cc1)​C(F)​(F)​F
InCHI Code
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​1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)​15-6-8-16(9-7-15)​23(24,25)​26)​19(29)​27-12-14-4-10-17(11-5-14)​32-22(2,3)​21(30)​31/h4-11H,12H2,1-3H3,(H,27,29)​(H,30,31)​
InCHI Key
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ILUPZUOBHCUBKB-UHFFFAOYSA-N

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GW 590735 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00
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Cart Total $0.00

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Pricing updated 2015-03-28. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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