Cayman Chemical Item Number 10010241

AICA Riboside; Acadesine; NSC 105823 (CAS 2627-69-2)

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AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.1 AICAR is a selective activator of AMP-activated protein kinase (AMPK) in both hepatocytes and adipocytes.2 At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.2 AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes.3 It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.4

1. Hardie, D.G., and Carling, D. The AMP-activated protein kinase. Fuel gauge of the mammalian cell? Eur J Biochem 246 259-273 (1997).

2. Corton, J.M., Gillespie, J.G., Hawley, S.A., et al. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229 558-565 (1995).

3. Salt, I.P., Connell, J.M.C., and Gould, G.W. 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 49 1649-1656 (2000).

4. Ayasolla, K.R., Giri, S., Singh, A.K., et al. 5-aminoimidazole-4-carboxamide-I-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia. J Neuroinflammation 2 1-21 (2005).

  • AICA Riboside
  • Acadesine
  • NSC 105823
Formal Name 5-​amino-​1-​β-​D-​ribofuranosyl-​1H-​imidazole-​4-​carboxamide
CAS Number 2627-69-2
Molecular Formula C9H14N4O5
Formula Weight 258.2
Formulation A crystalline solid
Purity ≥98%
λmax 268 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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AICAR is available in the following screening library:

Size Price Quantity Subtotal
50 mg $45.00 $0.00
100 mg $81.00 $0.00
250 mg $180.00 $0.00
500 mg $315.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA


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