SC-514

Cayman Chemical Item Number 10010267

(CAS 354812-17-2)

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Description

SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) (IC50 = 3-12 μM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK.1,2 In synovial fibroblasts stimulated with interleukin (IL)-1β, SC-514 attenuates NF-κB-mediated expression of IL-6, IL-8, and cyclooxygenase-2 (IC50s = 20, 20, and 8 μM, respectively).1 SC-514 also reduces NF-κB-mediated expression of other genes, including iNOS in LPS-stimulated smooth muscle cells3 and TLR2 in TNF-activated astrocytes.4

1. Kishore, N., Sommers, C., Mathialagan, S., et al. A selective IKK-2 inhibitor blocks NF-kB-dependent gene expression in interleukin-1b-stimulated synovial fibroblasts. J Biol Chem 278(35) 32861-32871 (2003).

2. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett 14 2817-2822 (2004).

3. Gomez, A.B., MacKenzie, C., Paul, A., et al. Selective inhibition of inhibitory kappa B kinase-b abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. Br J Pharmacol 146 217-225 (2005).

4. Phulwani, N.K., Esen, N., Syed, M.M., et al. TLR2 expression in astrocytes is induced by TNF-a-and NF-kB-dependent pathways. J Immunol 181 3841-3849 (2008).

Formal Name 4-​amino-​[2,​3'-​bithiophene]-​5-​carboxamide
CAS Number 354812-17-2
Molecular Formula C9H8N2OS2
Formula Weight 224.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(=O)​c1sc(cc1N)​c1cscc1
InCHI Code
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​1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)​14-8(6)​9(11)​12/h1-4H,10H2,(H2,11,12)​
InCHI Key
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BMUACLADCKCNKZ-UHFFFAOYSA-N

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Size Price Quantity Subtotal
5 mg $35.00 $0.00
10 mg $63.00 $0.00
25 mg $149.00 $0.00
50 mg $263.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-28. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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